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KMID : 0369819900200010001
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Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 1 p.1 ~ p.5
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Pharmacokinetic Interaction of Propranolol and Angiotensin Inhibitor in Rabbits
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최준식/Choi JS
이진환/범진필/Lee JH/Burm JP
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Abstract
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Effect of an angiotensin inhibitor (AAS; loading dose of 25, 50, 100μg/kg and maintenance dose of 12.5, 25,50μg/ka/hr) on the pharmacokinetics of propranolol (4 mg/kg i.v.) was studied in rabbits. Plasma concentrations and relative bioavailability of propranolal increased upto 127-175% by AAS coinjection. The urinary excretion of propranolol decreased by AAS. Dosage regimen of propranolol should be adjusted when it is administered with AAS.
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KEYWORD
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